General Stability | Organism |
---|---|
The enzyme is degraded by the proteasome and ubiquitinated. Enzyme turnover is triggered by a wide variety of sterols | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
endoplasmic reticulum | - |
Homo sapiens | 5783 | - |
nucleus | - |
Homo sapiens | 5634 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP+ | Homo sapiens | - |
4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + NADPH + H+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | O76062 | - |
- |
Homo sapiens | Q14739 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
BE(2)-C cell | - |
Homo sapiens | - |
blood | high expression | Homo sapiens | - |
brain | high expression | Homo sapiens | - |
colon | highest expression | Homo sapiens | - |
HeLa cell | - |
Homo sapiens | - |
Huh-7 cell | - |
Homo sapiens | - |
liver | high expression | Homo sapiens | - |
skin | highest expression in sun-exposed skin | Homo sapiens | - |
spleen | high expression | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP+ | - |
Homo sapiens | 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + NADPH + H+ | - |
? | |
dihydro-follicular fluid meiosis-activating sterol + NADPH + H+ | - |
Homo sapiens | dihydro-testis meiosis-activating sterol + NADP+ | - |
? | |
follicular fluid meiosis-activating sterol + NADPH + H+ | - |
Homo sapiens | testis meiosis-activating sterol + NADP+ | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 50000, SDS-PAGE | Homo sapiens |
? | x * 370000, SDS-PAGE | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
14-dehydrocholesterol reductase | - |
Homo sapiens |
C14-SR | - |
Homo sapiens |
C14-sterol reductase | - |
Homo sapiens |
DHCR14 | - |
Homo sapiens |
lamin-B receptor | - |
Homo sapiens |
LBR | - |
Homo sapiens |
TM7SF2 | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADP+ | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | when cholesterol levels are high, enzyme gene expression is inhibited | down |
Homo sapiens | under conditions of low cholesterol, enzyme gene expression is up-regulated by SREBP-2 | up |